Certified Dialysis Nurse Practice Test

Intrinsic or intrarenal kidney failure refers to a type of renal failure that occurs due to direct damage to the kidney tissues themselves. One of the most common causes of this type of failure is exposure to toxins or medications. Nephrotoxic agents, which can include certain antibiotics, non-steroidal anti-inflammatory drugs (NSAIDs), and contrast dyes, can cause harm to the renal tubules or glomeruli. This damage impairs the kidneys' ability to filter waste effectively, leading to a decrease in urine output and accumulation of toxins in the blood. Understanding this mechanism is essential because it highlights the need for careful medication management in patients who have existing renal impairment or are at risk for kidney disease. Ensuring appropriate use of medications and monitoring renal function can help prevent the progression of kidney injury in susceptible individuals.